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KMID : 1189420070200010154
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2007 Volume.20 No. 1 p.154 ~ p.168
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Effects of Agrimoniae Herba Ledebour on steptozotocin-induced Diabetic Mellitus in Rats
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Um Yu-Sik
Kim Kyung-Jun
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Abstract
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Objective: The present study was carried out to investigate the preventive effect of Agrimonia pilosa Ledebour on Streptozotocin(STZ)-induced Diabetes mellitus.
Method: Agrimonia pilosa Ledebour was given to rats with oral administration. The experimental animals were divided into 3groups : normal group of rats, control group of STZ-induced diabetic rats, sample group with Agrimonia pilosa Ledebour. The effect of Agrimonia pilosa Ledebour on STZ-induced diabetes was observed by measuring the survival rate of rats, weight of rats, FER, blood glucose, each organ weight of rat, total cholesterol, HDL, GOT, GPT & creatinine.
Result: STZ caused hyperglycemia and hypoinsulinemia by a selectively destroying pancreatic ?-cell. Agrimonia pilosa Ledebour treatment don’t protected them from hyperglycemia and hypoinsulinemia. Organ weight only liver weight decreased but kidney, heart & spleen shows no significant changes. Agrimonia pilosa Ledebour significantly don’t recoverd the increase of several biochemical parameters such as blood glucose, total cholesterol, HDL, GOT, GPT & creatinine is vice versa.
Conclusion: Agrimonia pilosa Ledebour extract group did not show significant difference compared with STZ-induced Diabetes Mellitus group.
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KEYWORD
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AgrimoniapilosaLedebour, DiabetesMellitus, Streptozotocin
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